Abstract
To summarize the seroprevalence of human herpesvirus 8 (HHV-8) in mainland China, we conducted a systematic review and meta-analysis based on available literature. Data show that differences in HHV-8 prevalence vary considerably among different ethnic groups and geographic regions. Blood-borne transmission could be a potential route for HHV-8 infection in China.
Highlights
Human herpesvirus 8 (HHV-8) is the infectious etiologic agent associated with Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease
Five studies, including 4,637 persons of Han ethnicity and 4,011 persons of ethnic minorities (2,040 Uygur, 1,169 Kazak, 200 Khalkas, 173 Hue, and 429 other) conducted in the Xinjiang Uygur Autonomous Region were analyzed for association of ethnicity with human herpesvirus 8 (HHV-8) prevalence
This systematic review indicated that HHV-8 prevalence in China varies in different regions
Summary
Human herpesvirus 8 (HHV-8) is the infectious etiologic agent associated with Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. A substantial number (35.5%) of these studies were conducted in the Xinjiang Uygur Autonomous Region. Among IVDUs, the prevalence was 34.3% (95% CI 28.3–40.3) in Zhejiang and 29.6% (95% CI 25.3–33.9) in Xinjiang Uygur Autonomous Region (online Technical Appendix Table 2; Figure).
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