Abstract
Frequency and clinical characteristics of primary human herpesvirus 6 (HHV-6) infection in hospitalized children with febrile seizures (FS) were investigated at Aghia Sophia Children’s Hospital and Laiko General Hospital, Athens, Greece.
Highlights
Using PCR in acute phase plasma and indirect immunofluorescent assay for antibody titers in acute and convalescent sera, primary human herpesvirus 6 (HHV-6) infection was verified in 10 (18%) with a first febrile seizures (FS)
None of 85 control subjects had primary HHV-6 infection, but 49% had immunoglobulin G antibodies against the virus
Testing for HHV-6 infection is recommended as a routine laboratory test in young children admitted to the ED in Greece for first occurrence of a FS
Summary
HUMAN HERPESVIRUS 6 INFECTION AND FEBRILE SEIZURES Frequency and clinical characteristics of primary human herpesvirus 6 (HHV-6) infection in hospitalized children with febrile seizures (FS) were investigated at Aghia Sophia Children's Hospital and Laiko General Hospital, Athens, Greece. Of 130 children with FS admitted during the study period, 65 returned for follow-up and were included; 55 had a first FS and 10 the second. Using PCR in acute phase plasma and indirect immunofluorescent assay for antibody titers in acute and convalescent sera, primary HHV-6 infection was verified in 10 (18%) with a first FS.
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