Abstract
BackgroundHuman herpesvirus 8 (HHV-8) infection is etiologically related to Kaposi’s sarcoma. Antibodies directed against HHV-8 can be detected in 80-95% of HIV-seropositive patients with KS. HHV-8 serological tests have been done in several countries in Southeast Asia such as Malaysia, and Thailand however no serological data is available in Indonesia. This study was to examine the presence of HHV- 8 antibodies in HIV-positive patients in Surabaya, Indonesia.Material and methodsNinety-one serum samples were collected from HIVpositive patients in Surabaya, Indonesia. Human immunodeficiency virus-positive serum samples were collected from 10 homosexual men, 25 intravenous drug users (IVDUs) and 56 heterosexuals. Serums were then tested for the presence of HHV-8 antibody by using sandwich ELISA (Abbexa Ltd, Cambridge, UK).ResultsThe total of 91 HIV-infected were testing with antibodies to HHV-8 using enzyme-linked immunosorbent assay. Antibodies of HHV-8 were detected in 7/91 (7.7%) of the samples. According to a gender, six men (85.7%) and a women (14.3%) were positive of HHV-8 antibodies. No correlation regarding the gender and age from this study. The antibodies of HHV-8 was detected among intravenous drug users (IVDUs) men 5/7 (42.8%) and 2/7 (28.6%) from homosexual and heterosexual, respectively.ConclusionThis study found the presence of HHV-8 antibodies in 7.7% of patients in Surabaya, Indonesia. This finding was higher more than Southeast Asian countries. The patients with a positive result could suggest measures to prevent HHV-8 infection.
Highlights
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the γ-herpesvirinae subfamily
E Human herpesvirus 8 n (HHV-8) serological tests have been done in s several countries in Southeast Asia such as u Malaysia, and Thailand no serol logical data is available in Indonesia
This study found the pres- epidemiology of Kaposi’s sarcoma.[9] ence of HHV-8 antibodies in 7.7% of patients in Surabaya, Indonesia
Summary
HHV-8 or KSHV, the only known human herpesvirus (rhadinovirus), is the most recently discovered tumor virus.[4] The genome of KSHV is a linear and the length about 165 to 170 kb.[5] This virus is covered by a tegument containing protein, and closed during budding of the cell. These membranes originate from the outer envelope of the lipid membrane from various specific viral hosts and glycoproteins.[6] It may exist in a circular episomal form part by a Grant-in-Aid from Dato’ Sri Prof.
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