Human health risk assessment of antibiotics in binary mixtures for finished drinking water

Abstract

The present study developed a new step-wise approach to estimate the potential human health risk of antibiotics in binary mixture for drinking water samples for two different sub-populations. Monte Carlo simulation based uncertainty analysis was performed to reduce uncertainty in risk assessment. Human health risk assessment studies were carried out using the acceptable daily intake (ADIs) for exposures of individual antibiotics considering point of departure (POD) and uncertainty factors (UFs). The estimated ADI values were used to estimate the predicted no effect concentrations (PNECs), at or below which no adverse human health effects are anticipated. Hazard quotient (HQ) in risk assessment was calculated as a ratio of environmental concentrations (ECs) and PNECs (EC/PNEC). The study showed that the average HQs values of individual antibiotics in adult and children were found below the acceptable limit, demonstrating no possible human health risk for both the subgroups. HIinteraction values of antibiotics in binary mixture was calculated using HQ values of antibiotics. The study observed that the estimated HIinteraction values of antibiotics in binary mixture was found to be less than 1 for both the sub populations, indicating no potential adverse effects on human health. Concentration of antibiotics was the primary contributor (>65%) to the overall variance in the uncertainty estimates for HQs of individual antibiotics in drinking water for adult and children. The co-occurrence of antibiotics in binary mixture for drinking water samples doesn't possess any possible risk on human health for the studied population.