Abstract
Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communities practicing traditional subsistence strategies whose microbiomes differ markedly from industrialists—remains unknown. Cardiovascular diseases are the leading cause of mortality in India affecting 55 million people, and high blood pressure is one of the primary risk factors for cardiovascular diseases. We examined associations between gut microbiome and blood pressure along with 14 other variables associated with lifestyle, dietary habits, disease conditions, and clinical blood markers in the three Assamese populations. Our analysis reveals a robust link between the gut microbiome diversity and composition and systolic blood pressure. Moreover, several genera previously associated with hypertension in non-Indian populations were also associated with systolic blood pressure in this cohort and these genera were predictors of elevated blood pressure in these populations. These findings confer opportunities to design personalized, preventative, and targeted interventions harnessing the gut microbiome to tackle the burden of cardiovascular diseases in India.
Highlights
Tulsi Kumari Joishy,1,2 Aashish Jha,3 Mai Oudah,4 Santanu Das,1,2 Atanu Adak,1 Dibyayan Deb,1,2 and Mojibur Rohman Khan 1
Several genera previously associated with hypertension in non-Indian populations were associated with systolic blood pressure in this cohort and these genera were predictors of elevated blood pressure in these populations. ese findings confer opportunities to design personalized, preventative, and targeted interventions harnessing the gut microbiome to tackle the burden of cardiovascular diseases in India
Most of the studies investigating the role of gut microbiome (GM) on the etiology of hypertension and other chronic diseases have focused on industrialized populations such as Americans [1, 17], Europeans [1, 16], and Chinese living in modern cities [8]
Summary
Tulsi Kumari Joishy ,1,2 Aashish Jha ,3 Mai Oudah ,4 Santanu Das ,1,2 Atanu Adak ,1 Dibyayan Deb ,1,2 and Mojibur Rohman Khan 1. We examined associations between gut microbiome and blood pressure along with 14 other variables associated with lifestyle, dietary habits, disease conditions, and clinical blood markers in the three Assamese populations. Erefore, identifying gut microbial features associated with high blood pressure can lead to novel preventative and therapeutic approaches that are urgently needed to address the high burden of cardiovascular disease in India. We evaluated the relationship between the gut microbiome and 22 host factors, including blood pressure in 71 healthy Assamese individuals from three rural villages in Assam, a Northeastern Indian state with high prevalence of hypertension [23, 24]. After accounting for lifestyle, we were able to identify a robust association between different measures of gut microbiome and systolic blood pressure in these individuals. Using a machine learning approach, we were able to identify several bacterial taxa that are predictive of elevated blood pressure in this Indian population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
