Abstract
1. 1. Oxidation of the methionine of N-formyl-methionyl-leucyl-phenylalanine to the sulfoxide or sulfone derivative results in the loss of the peptide's chemotactic activity for human granuloctyes. 2. 2. The oxidized peptides are chemotactic for human monocytes; however, 10- to 100-fold higher concentrations are required for optimal monocyte chemotaxis. 3. 3. Mouse, guinea pig and rabbit granulocytes, and the WBC264-9 human-mouse hybrid cell line migrated to the oxidized peptides and required 10- to 1000-fold higher concentrations of the oxidized peptides to elicit optimal chemotactic responses. 4. 4. Human granulocytes appear to be unique in their lack of responsiveness to oxidized derivatives.
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More From: Comparative Biochemistry and Physiology -- Part A: Physiology
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