Abstract
Human granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is a regulatory glycoprotein that stimulates the production of granulocytes and macrophages from committed hematopoietic progenitor cells both in vitro and in vivo. In this report, we show that recomhinant human GM‐CSF enhances colony formation by nonhematopoietic human ovarian cancer cell lines, IGROV‐1, A2774, ME‐180, Pa‐1 and A2780. GM‐CSF also enhanced the colony formation by cells obtained from fresh ascites of a patient with ovarian mucinous cystadenocarcinoma and a patient with serous papillary ovarian carcinoma. Our observations were made with GM‐CSF concentrations between 0.1 to 1 ng/ ml; these concentrations are equivalent to the dosages generally used for bone marrow recovery after chemotherapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
