Abstract
Mesenchymal stem cells (MSCs) are fibroblast-like cells, which exhibit self-renewal, multilineage differentiation potential and immunomodulatory properties. MSCs, initially identified from bone marrow, started a new era in regenerative medicine and have demonstrated the therapeutic potentials for the treatment of important degenerative diseases of both animals and humans. The MSC-like cells also exist in many other organs including different dental tissues. Dental tissue-derived MSCs are homogenous, proliferate faster than bone marrow-derived MSCs, and also differentiate into multiple cell types. Among the different dental tissues, gingival tissue is easily accessible and MSCs are readily isolated, which possess an excellent immunomodulatory and anti-inflammatory properties in both in vitro and in vivo conditions. Gingival MSCs also have shown potent regenerative capacity to other cell types in vivo. In this article, I will discuss about the unique characteristics and regenerative potential of gingival tissue-derived MSCs.
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