Abstract
Human Genetic Association Studies: association between of Human genome with Clinical outcome
Highlights
The achievements of Human Genome Project and subsequent advancements in Genotyping have led to an influx of exciting new developments in genetics
There is a strong relationship between geographic correlation and genetics similarity of an individual who resides in Europe, but there is a considerable overlap of genetic similarity among neighboring European subpopulations which determines accurate determinations for genetic variability[4]
Phenotypical Variance Incorporated into Genomic Studies and SNPsthe genetic effect of Single Nucleotide Polymorphisms (SNPs) on the phenotype of an individual depends on the number of contributing SNPs and non-genetic influences like environmental effects, in determining accurately an identity of a person
Summary
Human Genetic Association Studies: association between of Human genome with Clinical outcome. The methods employed have been optimized to examine the application of Genome Wide Association Studies with population based forensic investigations. Genome Wide Association Studies associated approaches have been incorporated in routine clinical practice. The study of genomic and associated genetic markers requires the step wise following of techniques like firstly, a set of information about genotype and phenotype relationship need to be established and identified[2]. The modeling for the mixture sample that is under consideration for estimating phenotype and genotype relationship needs to be optimized to deliver highest set of information. It can be possible to assess Single Nucleotide Polymorphisms (SNPs) in determining genotype for each sample, before the execution of costly Genome Associated Studies or Genome Sequencing into practice[2]
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