Abstract
Multiligand binding, multifunctional protein, hyaluronan-binding protein 1 (HABP1/SF2-p32/gC1qR) purified and characterized by our laboratory, is revealed to be present in different cellular compartments under various physiological conditions. While unearthing the functions of HABP1, its regulatory involvement in several cellular processes like cellular growth, cell cycle regulation, host-pathogen interaction, apoptosis induction and autophagic vacuole formation has been reported. The role of this protein in regulation of tumorigenesis has been validated as it promotes cellular migration in melanoma cells, shows increased tumor potency with its overexpression in HepG2 cell line and is present in higher levels in tumor tissues. Here, we have tried to explain the probable mechanism of its involvement in tumor pathogenesis. The fact that HABP1 co-purifies with the RNA splicing factor SF2/ASF/SRSF1 is taken into consideration along with the reports of SF2 being an oncogene, which indicates a possible involvement of HABP1 in splicing reactions having an impact on cellular proliferation and tumorigenesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
