Abstract
Results There were no differences found in the HE4 levels determined for the mothers' blood samples and umbilical cord blood samples in all investigated groups. In comparison with healthy children, the elevated HE4 levels were observed in neonates with TTN. Significant positive correlation between HE4 and CRP as well as PCT levels was observed in all investigated neonates. The receiver operating characteristic (ROC) curve analysis demonstrated the cut-off value for the serum HE4 in the researched neonates at the level of 318.5 pmol/L, yielding the sensitivity of 73.9% and specificity of 66.7% for the early diagnosis of TTN. Conclusions Serum HE4 could be considered as a candidate biomarker for the early diagnosis of pulmonary dysfunction in the newborns.
Highlights
Transient tachypnea of the newborn (TTN) is one of the most common causes of respiratory distress in the full-term neonates
The investigated neonates were divided into two groups: 23 neonates with the respiratory insufficiency as the study group and 28 newborn babies of healthy mothers constituted the control group (CG)
There were no significant differences in birth weight, gender, and Apgar score between the group of neonates with TTN compared with controls (Table 1)
Summary
Transient tachypnea of the newborn (TTN) is one of the most common causes of respiratory distress in the full-term neonates. The authors investigated the HE4 levels found in the umbilical cord blood and venous blood samples of the newborns with respiratory disorder (TTN) and blood samples of their mothers. The receiver operating characteristic (ROC) curve analysis demonstrated the cut-off value for the serum HE4 in the researched neonates at the level of 318.5 pmol/L, yielding the sensitivity of 73.9% and specificity of 66.7% for the early diagnosis of TTN. Transient tachypnea of the newborn (TTN) is one of the most common causes of respiratory distress in neonatal period, affecting 0.5% to approximately 5% of all late preterm and term neonates in the immediate postdelivery period [1,2,3]. The markers should be highly specific and sensitive
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