Abstract
Background: The human epidermal growth factor family (HER) members play a significant role in the mesenchymal-to-epithelial transition during renal tubulogenesis. HER misexpression has been linked also to loss of growth control, invasiveness, and promotion of angiogenesis in breast cancers and other human malignant tumors Methods: The authors screened Wilms’ tumor samples and derived cell lines for expression of her2/ neu, which was detected in both unfavorable and favorable histology tissues. Xenografts were implanted in mice using her2/ neu(+) and her2/ neu(−) cell lines and the effect of specific blockade tested using monoclonal anti-her2/ neu antibody. Results: Blocking antibody suppressed tumor growth in her2/ neu(+) but not her2/ neu(−) experimental Wilms’ tumor. In addition, antibody exposure resulted in suppression of tumor angiogenesis but no decrease in tumor cell proliferation in her2/ neu(+) xenografts. Conclusions: Her2/ neu contributes to the growth of some Wilms’ tumors, and an important mechanism of its action is promotion of angiogenesis.
Published Version
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