Abstract
Human Environmental Disease Network: Deciphering disease-disease and chemicaldisease associations using chemical contaminants information_suppl
Highlights
It is well established that genes and environmental factors influence common human diseases, understanding disease-causing defects is still a challenge (Hunter, 2005)
Three cases fall under this category: (a) the chemical toxicity is well known and the chemical is recognized to cause the disease, (b) the causal associations have been found in recent, large, prospective or retrospective cohort studies, and (c) the chemicals are listed as group 1 human carcinogens by the International Agency for Research on Cancer (IARC)2
Diseases and gene ontology (GO) information were integrated from two different sources in each gene/protein list
Summary
It is well established that genes and environmental factors influence common human diseases, understanding disease-causing defects is still a challenge (Hunter, 2005). Several network based approaches have allowed deciphering disease comorbidity (Goh et al, 2007; Lee et al, 2008; Hidalgo et al, 2009; Suthram et al, 2010; Davis and Chawla, 2011; Sun et al, 2014a; Menche et al, 2015). Roque et al (2011) created an approach to gather phenotypic descriptions of patients from medical records that would suggest new disease-disease associations. All these studies provide comprehensive views of links between diseases, they all rely on existing knowledge, i.e., genes, pathways and phenotypic associations (Hidalgo et al, 2009)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
