Abstract
The aim of present study was to investigate the association of the ENPP1 (K121Q) gene polymorphism with DKD in eastern Uttar Pradesh population. A total of 162 DKD and 155 apparently healthy controls were enrolled and K121Q polymorphism was determined by PCR-RFLP followed by sequencing. It was observed that genotype KQ was more frequent in patients than controls and allelic frequencies of Q allele were higher in DKD (Q 21.3%) than control (Q 15.81%). It depicted that Q allele may be associated with DKD patient and has more risk in eastern UP population. The study indicated a significant association of KQ polymorphism of the ENPP1 gene with DKD in the eastern Uttar Pradesh population.
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