Abstract
Antisense oligodeoxynucleotides to endothelin ET A receptor mRNA were used to characterize vascular smooth muscle receptors. The concentration-response curve showed a significant attenuation of endothelin-1-induced contraction in circular segments of the human superficial temporal artery. Endothelin ET B receptor antisense or mismatch oligodeoxynucleotides showed no alteration of the endothelin-1-induced contraction. Complementary experiments with the selective endothelin ET A receptor antagonist FR139317 demonstrated a shift of the concentration-response curve to the right in a competitive manner (pA 2 = 6.93). The specific method of using the receptor antisense oligodeoxynucleotides approach revealed the presence of endothelin ET A receptors mediating contraction in the human superficial temporal artery.
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