Abstract
In this chapter, we will review some aspects of work in our laboratory on the control of growth and differentiation in human teratocarcinoma stem cells. We begin by describing the three cell types which we have isolated in vitro from human teratomas: embryonal carcinoma, yolk sac carcinoma resembling visceral endoderm (solid yolk sac carcinoma), and yolk sac carcinoma resembling parietal endoderm (endodermal sinus tumour). Next, we discuss the development of a new panel of monoclonal antibodies for the study of cell differentiation lineage in human teratomas. We then describe properties of a spontaneously differentiating multipotent clone of human embryonal carcinoma, and we present evidence of possible paracrine growth interaction between teratocarcinoma stem cells and yolk sac carcinoma cells.
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