Abstract
Objective To investigate human cytomegalovirus (HCMV) load in urine of neonates with congenital infection and correlate this with clinical symptoms of HCMV disease.Methods Urine samples were obtained from 98 neonates with HCMV infection confirmed by polymerase chain reaction (PCR).HCMV loads in urine samples were detected by Real-time fluorescence quantitative PCR (FQ-PCR).Results Ninety-eight infants with congenital HCMV infection were included.Eighty-five/98 (86％) congenitally infected infants had clinical symptoms of HCMV infection at birth.The median HCMV load in asymptomatic infants was significantly lower than that in infected infants with clinical symptoms (1.4 × 105copies/ml versus 3.1 × 106copies/ml,P ＜ 0.01,respectively).Conclusion HCMV load in,urine of neonates with congenital infection is significantly lower in asymptomatic infants than in infants with clinical symptoms.It indicated that the HCMV load in urine is correlated with disease severity. Key words: Cytomegalovirus infection; Polymerase chain reaction; Viral load
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