Abstract
The retrosplenial complex (RSC) plays a crucial role in spatial orientation by computing heading direction and translating between distinct spatial reference frames based on multi-sensory information. While invasive studies allow investigating heading computation in moving animals, established non-invasive analyses of human brain dynamics are restricted to stationary setups. To investigate the role of the RSC in heading computation of actively moving humans, we used a Mobile Brain/Body Imaging approach synchronizing electroencephalography with motion capture and virtual reality. Data from physically rotating participants were contrasted with rotations based only on visual flow. During physical rotation, varying rotation velocities were accompanied by pronounced wide frequency band synchronization in RSC, the parietal and occipital cortices. In contrast, the visual flow rotation condition was associated with pronounced alpha band desynchronization, replicating previous findings in desktop navigation studies, and notably absent during physical rotation. These results suggest an involvement of the human RSC in heading computation based on visual, vestibular, and proprioceptive input and implicate revisiting traditional findings of alpha desynchronization in areas of the navigation network during spatial orientation in movement-restricted participants.
Highlights
The retrosplenial complex (RSC) plays a crucial role in spatial orientation by computing heading direction and translating between distinct spatial reference frames based on multi-sensory information
We demonstrate the modulation of neural dynamics in the human RSC and other regions of the human navigation network during heading computation in a spatial orienting task
Heading reproduction was more accurate when participants physically rotated compared to a stationary setup using a joystick, reflecting the synergistic use of idiothetic information during active m
Summary
The retrosplenial complex (RSC) plays a crucial role in spatial orientation by computing heading direction and translating between distinct spatial reference frames based on multi-sensory information. The visual flow rotation condition was associated with pronounced alpha band desynchronization, replicating previous findings in desktop navigation studies, and notably absent during physical rotation These results suggest an involvement of the human RSC in heading computation based on visual, vestibular, and proprioceptive input and implicate revisiting traditional findings of alpha desynchronization in areas of the navigation network during spatial orientation in movement-restricted participants. It hosts subpopulations of heading-sensitive cells that are sentient to local features of the environment, while other cells exhibit mixed activity patterns related to both local and global heading c omputation[5] These findings suggest that neural activity in the RSC subserves the integration of egocentrically (view-point dependent) coded landmark cues based on sensory fusion vision and p. This allows the compensation of rotational offsets between egocentric and allocentric spatial representations, routed from the parietal and medial temporal cortices, providing the necessary information for translating between both frames of reference in the R
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