Abstract
The present survey of the structure and reactions of human coronal dentine demonstrates the need for a thorough knowledge of this tissue if one is to understand the biology of the pulp. Particular attention is paid to conditions which result in increased mineralization of the primary dentine, for these conditions may reduce dentine permeability and thus probably modify the pulp reactions which may occur. In order to prevent damage to the pulp, it is possible that treatment should be aimed toward a reduction in the permeability of the dentine rather than toward an attempt to stimulate irregular secondary dentine formation.
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