Abstract
The genetic polymorphism of the A subunit of human coagulation factor XIII (FXIIIA) was investigated in platelet lysates from 239 blood donors from Hessen, Germany, and thereby for the first time in an European population. FXIIIA activity was detected by using a monospecific rabbit anti-human factor XIII subunit A antiserum for immunofixation after high voltage thin-layer agarose gel electrophoresis (IAGE). Three common phenotypes were observed (FXIII A 1, 2-1, and 2). The calculated allele frequencies were FXIIIA*1=0.797 and FXIIIA*2=0.203. The application of the FXIIIA polymorphism in blood group genetics is discussed.
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