Human CO Model of Creutzfeldt - Jakob Disease (CJD) Evaluates the Effect of Putative Drugs on Prion Accumulation

Abstract

Creutzfeldt Jakob Disease (CJD) is incurable and fatal neurodegenerative disease. The treatment in human is cell based models for prion disease. An induced pluripotent stem cell based models of human cerebral organ has shown to cure CJD prions. This model has new screening methodology for drug induced candidates in certain genetic background. Using anti-prion disease, first ever model was screened for drug induced patients. Pentason polysulfate delayed methodology along with prophylactic has been a remedy for treatment. These are the first regenerative treatment that can concur results for CJD.