Abstract
ObjectiveTo compare gestational age (GA) estimates in early pregnancy, determined by last menstrual period (LMP), human chorionic gonadotropin (hCG) concentration, ultrasound crown–rump length (Hadlock formula), and ovulation day (luteinizing hormone surge plus 1day). MethodsFemale volunteers seeking to conceive (at 5 US sites) collected daily early-morning urine for up to 3 menstrual cycles. Pregnant women underwent ultrasound dating scans. Conception cycle urine was quantitatively assessed for luteinizing hormone and hCG. Summary statistics for GA using each reference method were determined (n=131). ResultsCorrelation between GA determined by ultrasound and ovulation day was excellent (maximum difference 10days); however, pregnancies dated by ultrasound were 3days advanced. The difference between LMP estimates and estimates based on ovulation day or ultrasound was 9 and 12days, respectively. A uniform rise in hCG on each day of pregnancy was seen using all reference methods. The accuracy of hCG measurement in determining the week since conception was more than 93%. ConclusionMethods for establishing pregnancy duration vary in their accuracy and their GA estimates. The rise in hCG concentration in early pregnancy is uniform and therefore hCG levels provide the most accurate, early estimation of GA in single, viable pregnancies.ClinicalTrials.gov:NCT01077583
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Gynecology & Obstetrics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.