Abstract
Sepsis continues to be a major cause of morbidity, mortality, and post-recovery disability in patients with a wide range of non-infectious and infectious inflammatory disorders, including COVID-19. The clinical onset of sepsis is often marked by the explosive release into the extracellular fluids of a multiplicity of host-derived cytokines and other pro-inflammatory hormone-like messengers from endogenous sources (“cytokine storm”). In patients with sepsis, therapies to counter the pro-inflammatory torrent, even when administered early, typically fall short. The major focus of our proposed essay is to promote pre-clinical studies with hCG (human chorionic gonadotropin) as a potential anti-inflammatory therapy for sepsis.
Highlights
We propose to use well-studied hormones and their analogs, individually and in unison with mice treated with broad-spectrum antibiotics, likely to suffer from sepsis
Other well-known roles of this hormone are to promote angiogenesis within the uterus, preserve progesterone production by the corpus luteum, maintain myometrial quiescence, and maintain local immune tolerance [40, 74]. In addition to these roles associated with pregnancy, human chorionic gonadotropin (hCG) shows a wide range of significant anti-inflammatory effects
HCG is a major pregnancy hormone that belongs to the glycoprotein family
Summary
SepsisSepsis is a clinical syndrome characterized by physiologic and biochemical abnormalities associated with organ injury caused by dysregulated host responses to infection (and or inflammation) [1]. This manuscript will catalog data that leads us to hypothesize that human chorionic gonadotropin (hCG) and its relatives from mammalian and microbial sources may provide benefits when administered early in sepsis. Non-placental normal human pituitary cells do secrete low levels of hCG into blood during the middle of menstrual cycle [49].
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