Abstract
ABSTRACT Human chorionic gonadotropin preparations (HCG) have previously been shown to contain at least 2 pregnancy specific immunogenic components (Ag #5 and Ag #6) by immunoelectrophoretic analysis. In this study Ag #5 and Ag #6 have been chromatographically separated and shown to consist of at least 3 distinct electrophoretic entities. These 3 entities have been characterized antigenically and biologically. A fraction (Fr I-I) containing Ag #6 and a previously undetected pregnancy specific antigen possessed only a portion of the antigenic and biologic activities present in HCG. A second fraction (Fr I-II) containing only the cathodic component of Ag #5 possessed all the antigenic and biologic specific activities in amounts equal to or greater than present in HCG. A third fraction (Fr II) containing only the anodic component of Ag #5 was antigenically and biologically similar to Fr I-II. However, the specific activity of Fr II was significantly greater than that of Fr I-II in 3 of 4 test indexes employe...
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