Abstract
Persistent alterations of the renal tissue due to maladaptive repair characterize the outcome of acute kidney injury (AKI), despite a clinical recovery. Acute damage may also limit the renal production of erythropoietin, with impairment of the hemopoietic response to ischemia and possible lack of its reno-protective action. We aimed to evaluate the effect of a cell therapy using human CD133+ renal progenitor cells on maladaptive repair and fibrosis following AKI in a model of glycerol-induced rhabdomyolysis. In parallel, we evaluated the effect of CD133+ cells on erythropoietin production. Administration of CD133+ cells promoted the restoration of the renal tissue, limiting the presence of markers of injury and pro-inflammatory molecules. In addition, it promoted angiogenesis and protected against fibrosis up to day 60. No effect of dermal fibroblasts was observed. Treatment with CD133+ cells, but not with PBS or fibroblasts, limited anemia and increased erythropoietin levels both in renal tissue and in circulation. Finally, CD133+ cells contributed to the local production of erythropoietin, as observed by detection of circulating human erythropoietin. CD133+ cells appear therefore an effective source for cell repair, able to restore renal functions, including erythropoietin release, and to limit long term maldifferentiation and fibrosis.
Highlights
Author’s Response o Author surnames have been highlighted – please check these carefully and indicate r if the first name or surname have been marked up incorrectly
We aimed to evaluate the effect of a cell therapy using human CD133+
We evaluated the effect of CD133+ cells on erythropoietin production
Summary
Author’s Response o Author surnames have been highlighted – please check these carefully and indicate r if the first name or surname have been marked up incorrectly. Please note that this p will affect indexing of your article, such as in PubMed. Please check and ensure that the licence type at the end of the paper matches the Uncorrected version on the Licence to Publish form submitted. Cells Induce Erythropoietin f Production and Limit Fibrosis After o Acute Tubular Injury o Shikhar Aggarwal[1], Cristina Grange[2], Corinne Iampietro[1], Giovanni Camussi2 & pr Benedetta Bussolati[1]. We evaluated the effect of CD133+ cells on erythropoietin production
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