Human-Borne Pathogens: Are They Threatening Wild Great Ape Populations?

Abstract

Simple SummaryHuman-driven activities, including agriculture, forestry, and mining, are destroying the natural habitats of wild great ape (bonobo, chimpanzee, gorilla, and orangutan) populations in Africa and Southeast Asia. The reduction in and fragmentation of wild great ape environments lead to (i) a decrease in population numbers, (ii) the isolation of current populations, and (iii) increased exposure to humans and their livestock. Consequently, the spatial overlap between humans and wild great apes might facilitate the transmission of infectious agents between them. Historically, animal-to-human pathogen transmission has attracted most of the attention of researchers and public health authorities. Only in recent years has the human-to-animal transmission pathway acquired notoriety, mainly due to conservation concerns. In this review, we examine and appraise literature-based evidence reporting wild great ape infections with viral, bacterial, parasitic, and fungal pathogens of potential anthropic nature. We select and further discuss two viral (Human Metapneumovirus and Respiratory Syncytial Virus), one bacterial (diarrhoeagenic Escherichia coli), and two parasitic (Cryptosporidium spp. and Giardia duodenalis) pathogens causing infections in wild great ape populations for which a human origin is most likely. Gaps in knowledge and future research directions are also identified.Climate change and anthropic activities are the two main factors explaining wild great ape habitat reduction and population decline. The extent to which human-borne infectious diseases are contributing to this trend is still poorly understood. This is due to insufficient or fragmented knowledge on the abundance and distribution of current wild great ape populations, the difficulty obtaining optimal biological samples for diagnostic testing, and the scarcity of pathogen typing data of sufficient quality. This review summarises current information on the most clinically relevant pathogens of viral, bacterial, parasitic, and fungal nature for which transmission from humans to wild great apes is suspected. After appraising the robustness of available epidemiological and/or molecular typing evidence, we attempt to categorise each pathogen according to its likelihood of truly being of human origin. We further discuss those agents for which anthroponotic transmission is more likely. These include two viral (Human Metapneumovirus and Respiratory Syncytial Virus), one bacterial (diarrhoeagenic Escherichia coli), and two parasitic (Cryptosporidium spp. and Giardia duodenalis) pathogens. Finally, we identify the main drawbacks impairing research on anthroponotic pathogen transmission in wild great apes and propose research lines that may contribute to bridging current knowledge gaps.