Abstract
Aberrant DNA methylation patterns are associated with many types of cancer. We are interested in understanding the faith of methyl donors implicated in the remethylation of homocysteine under extreme pathway overload and hepatic insulin resistance. The microenvironments known to affect epigenetic patterns and signaling between organs are being studied using DNA methylation arrays. The body‐on‐a‐chip is a microfabricated device combined with cell cultures. Several cell culture chambers are interconnected by microfluidic channels and present the same order of magnitude as in vivo cellular tissue constructs. This microdevice prevents dilution of important secretory factors with numerous advantages like volume reduction, dynamic cell culture and the possibility to accurately monitor the flow rate inside the microchannels. This human surrogate is being used to create a physiological microenvironment to study modulations of DNA methylation patterns and signaling between organ tissues such as GI/liver/Brain and adipose tissue. Modulations of input and surrogate biomarkers are being developed and plan to be immobilized within the device. This research is funded by The Department of Biomedical Engineering, Cornell University.
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