Abstract
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Highlights
Tuberculosis (TB) is an infectious disease caused in humans by several strains of mycobacterium, especially Mycobacterium tuberculosis (M. tb) [1]
After obtaining a written informed consent for this study, the participants were divided into three groups that comprised of 30 multi-drug-resistant TB (MDR-TB) patients, 30 drug-sensitive TB patients (DS-TB), and 30 non-TB, apparently healthy, individuals as controls
The mean levels of lysate and sputum Human Beta Defensin 1 (hBD1) were not significantly different in D0when compared with the controls
Summary
Tuberculosis (TB) is an infectious disease caused in humans by several strains of mycobacterium, especially Mycobacterium tuberculosis (M. tb) [1]. Resistance to TB drugs could result from inappropriate treatment with a single antiTB drug (usually isoniazid), wrong-drug prescription leading to ineffective treatment and may be due to the patient not taking the medication correctly, which can be due to a variety of reasons, including cost or scarcity of medicines, patient’s forgetfulness, or patient stopping treatment early because they feel better [4]. None of these reasons addressed innate intracellular components of cells involved in combating M. tb infection. Conclusion: Due to the higher levels of hBD1 in the sputum and lysate of M0 than in D0, one might conclude that there is a relationship between chronicity of PTB and hBD1 level
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