Abstract
This chapter provides an overview of human antimouse antibodies (HAMA). Development of HAMA is important with regard to repeated diagnostic or therapeutic applications, and with regard to the interference with specific in vitro immunoassays. The interference of HAMA in vitro with immunoassays using murine monoclonal antibodies for the detection of hormones, oncofetal, and tumor-associated antigens in serum can be overcome by addition of normal mouse serum to absorb the HAMA. Investigations of the development of human antimouse antibodies in patients with cancer, in patients undergoing diagnostic investigations, and in patients with autoimmune diseases led to the observations that pre-existing antibodies of the immunoglobulin M (IgM) class with an antimouse antibody activity show a strong correlation to the presence of IgM rheumatoid factors. There is a difference in the development of HAMA depending on the specificity of the mouse monoclonal antibody used.
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