Abstract
Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, and systemic flare induction. In addition, the role of the circadian clock is discussed. Evidence is compared in healthy individuals and SLE patients as well as in wild-type and lupus-prone mice. Further research is needed into the effects of UV light on cutaneous and systemic immune responses to understand how to prevent UV-light mediated lupus flares.
Highlights
Human and Murine Evidence for Mechanisms Driving Autoimmune PhotosensitivityEdited by: Anne Davidson, Feinstein Institute for Medical Research, United States
Ultraviolet (UV) light is a pervasive environmental exposure with pleotropic effects on the skin
UV exposure triggers reactive oxygen species (ROS) production, DNA damage, and apoptosis that can result in autoantigen translocation to the surface of keratinocytes where they are exposed for immune recognition by autoantibodies
Summary
Edited by: Anne Davidson, Feinstein Institute for Medical Research, United States. Reviewed by: Christian Jan Lood, University of Washington, United States Umesh S. Oklahoma Medical Research Foundation, United States Nicholas Arthur Soter, New York University, United States. Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, and systemic flare induction. Evidence is compared in healthy individuals and SLE patients as well as in wild-type and lupus-prone mice. Further research is needed into the effects of UV light on cutaneous and systemic immune responses to understand how to prevent UV-light mediated lupus flares
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