Abstract
Address: 1Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy, 2Institut Cochin, INSERM, CNRS, Paris, France, 3University of Milan, Milan, Italy, 4Istituto di Chimica del Riconoscimento molecolare, CNR, Milan, Italy, 5Istituto per lo studio delle macromolecole, CNR, Milan, Italy and 6Department of Obstetrics and Gynecology, San Raffaele Scientific Institute, Milan, Italy * Corresponding author
Highlights
The HIV-1 coreceptor CCR5 and antibodies against it are relevant for HIV-1 vaccine design and therapy
Antibodies to the first loop (ECL1) of CCR5 have been identified in HIV-exposed uninfected individuals (ESN) and in HIVpositive non-progressing subjects
To better define the role of anti CCR5 antibodies in blocking HIV infection, we characterized their role at mucosal level and we defined the fine epitope mapping
Summary
Human and chicken antibodies to CCR5-ECL1 block mucosal and systemic HIV infection. Lucia Lopalco*1,6, Claudia Pastori, Morgane Bomsel, Alberto Clivio, Chiara Alberti, Lorenzo Diomede, Renato Longhi, Giorgio Colombo, Roberto Consonni and Adriano Lazzarin. Address: 1Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy, 2Institut Cochin, INSERM, CNRS, Paris, France, 3University of Milan, Milan, Italy, 4Istituto di Chimica del Riconoscimento molecolare, CNR, Milan, Italy, 5Istituto per lo studio delle macromolecole, CNR, Milan, Italy and 6Department of Obstetrics and Gynecology, San Raffaele Scientific Institute, Milan, Italy. 2006 International Meeting of The Institute of Human Virology Meeting abstracts. A single PDF containing all abstracts in this Supplement is available here http://www.biomedcentral.com/content/pdf/1742-4690-3-S1-info.pdf
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