Abstract
To report on the use of human amniotic membrane for macular holes at 2 Canadian tertiary care centers. Retrospective cohort study. Twenty-two patients with persistent or chronic macular holes. Macular hole surgery was performed by 3 vitreoretinal surgeons. Macular hole closure with complete plugging by human amniotic membrane on spectral-domain OCT. The closure rate was 91% (20 of 22; median follow-up, 7 months), with no statistically significant visual acuity change overall. Complications included subretinal silicone oil (5%), choroidal neovascularization (5%), atrophy (5%), and cystoid macular edema (9%). Anatomical success with limited visual recovery was observed.
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