Human adenovirus Coinfection aggravates the severity of Mycoplasma pneumoniae pneumonia in children

Jiaojiao Gao,Baoping Xu,Kunling Shen,Lili Xu,Zhengde Xie

doi:10.1186/s12879-020-05152-x

Abstract

BackgroundMycoplasma pneumoniae (M. pneumoniae) is an important pathogen of community-acquired pneumonia (CAP) in children. The coinfection rate of M. pneumoniae pneumonia (MPP) can reach 52% in some areas, but the effects of coinfection with different pathogens have not been clearly recognized.MethodsThe cases of MPP hospitalized in Beijing Children’s Hospital from 1/1/2014 to 12/31/2016 were screened. MPP patients coinfected with Human adenovirus (HAdV) were categorized into the research group. Patients with single M. pneumoniae infection were categorized into the control group, matching the research group by age and admission time with a ratio of 1:3. Clinical manifestations, laboratory examinations, and disease severity were compared between these two groups.ResultsA total of 2540 hospitalized MPP cases were screened in Beijing Children’s Hospital, among which thirty cases were enrolled in the research group and ninety cases were enrolled in the control group. The results indicated that patients in the research group had longer hospital stays, longer fever durations and a higher rate of dyspnea, as well as a larger proportion applications of oxygen therapy and noninvasive continuous positive airway pressure (NCPAP). No obvious differences were found in lab examinations within the two groups. Regarding disease severity, the proportions of extremely severe pneumonia and severe disease defined by the clinical score system were higher in the research group than in the control group.ConclusionCompared with single M. pneumoniae infection, MPP coinfected with HAdV in children was relatively more serious.

Highlights

Mycoplasma pneumoniae (M. pneumoniae) is an important pathogen of community-acquired pneumonia (CAP) in children
Compared with M. pneumoniae mono-infection, patients coinfected with Human adenovirus (HAdV) had a longer hospital stay and fever duration and a higher rate of dyspnea, which led to a higher rate of oxygen therapy and noninvasive continuous positive airway pressure (NCPAP) use, as well as a higher proportion of extremely severe pneumonia and severe disease defined by the clinical score system
When Chin-Yung Chiu et al compared the clinical manifestations of M. pneumoniae mono-infection (n = 31), M. pneumoniae with Streptococcus pneumoniae coinfection (n = 9) and M. pneumoniae with virus coinfection (n = 19), these authors found that the fever duration of M. pneumoniaeand Streptococcus pneumoniae-infected children was Control group (n = 27)

Summary

Introduction

Mycoplasma pneumoniae (M. pneumoniae) is an important pathogen of community-acquired pneumonia (CAP) in children. The coinfection rate of M. pneumoniae pneumonia (MPP) can reach 52% in some areas, but the effects of coinfection with different pathogens have not been clearly recognized. Mycoplasma pneumoniae (M. pneumoniae) is an important pathogen of community-acquired pneumonia (CAP) in hospitalized children. M. pneumoniae is responsible for 20–40% of community-acquired bacterial pneumonia [2]. The detection rate of M. pneumoniae in pediatric CAP had a positive correlation with the increase in the age of the children [4]. The coinfection rate can reach 52% in Mycoplasma pneumoniae pneumonia (MPP) [10], but the effects of coinfection with other pathogens on the clinical features of MPP have not been clearly recognized

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