Abstract
•γδ T cells account for approximately 5% of CD3+ T cells in the blood and frequently express a Vγ9Vδ2 T-cell receptor•Vγ9Vδ2 T cells recognize pyrophosphate molecules that are produced by bacteria but also by many tumor cells•Vγ9Vδ2 T cells kill a broad variety of different tumor cells in an HLA-nonrestricted fashion•Vγ9Vδ2 T cell activation and expansion can be manipulated pharmacologically, e.g. by nitrogen-containing bisphosphonates•Vγ9Vδ2 T cells are attractive candiates for cellular immuotherapy
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