Huge typical pulmonary carcinoid presented with gigantism syndrome

Morris Beshay,Christina Förster,Fritz Mertzlufft,Beatrice Ariane Windmöller,Federico Gutierrez

doi:10.1007/s11748-020-01445-9

Abstract

A 27-year-old male patient presented with cough and right-sided, light thoracic pain. His physical appearance showed typical features of gigantism. Subsequently, further diagnostic work-up showed elevated level of growth hormone and a huge tumor of the right lung, identifying a typical pulmonary carcinoid tumor (TPCT). Curative surgery was performed leading to normalization of the elevated growth hormone levels few days after surgery. Two- and five-year follow-up showed no signs of recurrence. Respected to tumor size, we determined the largest TPCT to be reported in medical literature history.

Highlights

CasePulmonary carcinoids were initially labeled as adenomas of the bronchial system [1]
We report an exceptional huge typical pulmonary carcinoid tumor (TPCT) in a young male patient with gigantism syndrome
Due to the increased production of growth hormone, we postulate that the cause of gigantism in this patient was caused by this active TPCT

Summary

Introduction

Pulmonary carcinoids were initially labeled as adenomas of the bronchial system [1]. most classic carcinoids are located centrally, a few are found in the periphery of the lung [2]. Carcinoid tumors of the lung, such as of the intestinal tract, are derived from neuroendocrine Kulchitsky cells located within the bronchial or intestinal mucosa. These tumors may produce a number of peptides, such as serotonin, for example. A 27-year-old, non-smoking, 197 cm tall, 118 kg weight male patient presented himself at an external medical practice with symptoms including cough and right-sided, thoracic pain. The patient is recurrence-free and under follow-up (2- and 5- and 10-year follow-up was done performing CT scans)

Discussion

Findings

Conclusion