Hubungan prostate specific antigen (PSA) dengan rasio stromal epitelial prostat pada pasien pembesaran prostat jinak

Abstract

Background: Benign Prostatic Hyperplasia is the most common benign lesion in male. Imbalance between proliferation and apoptotic is the cause of benign prostatic hyperplasia. Epithelial and stromal growths are associated with active proliferation that influenced by many factors and mechanism, including Epithelial Mesenchymal Transition. Prostate Specific Antigen (BPH) has role in prostate’s stromal epithelial ratio changing in patient with benign prostatic hyperplasia. Aim of the study is to determine the correlation between Prostate Specific Antigen with stromal epithelial ratio of prostate in patient with benign prostate hyperplasia.Methods: 83 BPH patients, 50 to 80 years old with 20 to 80 grams prostates from ultrasound examination who underwent prostate trans uretra resection, had blood PSA examination and prostate specimens examination to evaluate the stromal epithelial ratio.  The data will be analize statistically.Result: Prostate Specific Antigen has negative correlation with stromal epithelial ratio r -0,28 with p 0,01. PSA is autocrine for epithelial cells and paracrine for stromal cells and stimulate proliferations in both cells.Conclusion: Prostate specific antigen has negative correlation with stromal epithelial ratio.