Hubungan Kadar Feritin Serum dengan Tes Fungsi Hati pada Pasien Thalasemia Mayor

Abstract

Thalassemia is a disease characterized by the destruction of red blood cells so that the life of red blood cells becomes shorter than normal erythrocytes. Thalassemia sufferers need routine blood transfusions throughout their lives, which results in a buildup or excess iron that causes damage to the body's organs, one of which is the liver. Iron in the body binds to ferritin and is stored in the liver. Ferritin examination is needed to see the excess or storage of iron in the body, while SGOT and SGPT are required to describe liver cell damage due to iron hoarding. This study aims to see the relationship between serum ferritin levels and liver function tests and the connection between adherence to consuming iron chelation and ferritin levels of thalassemia major patients. This study is an analytical observational study using a Cross-Sectional approach, with the subjects of the study being 22 children of Thalassemia Major who met the inclusion criteria for Ferritin, SGOT, and SGPT examinations. The results of the Spearman correlation test showed no relationship between serum ferritin levels with SGPT levels (sig. value 0.776) or SGOT (sig. value 0.766). Eta's correlation test for adherence to consuming iron chelation will affect serum ferritin by 36.2% in Thalassemia Major children at Dr. Tjitrowardojo Purworejo Hospital.