Abstract
Objective: This study was designed to determine the effect of high-quality nursing (HQN) combined with enteral nutrition support (ENS) in patients with acute pancreatitis (AP). Methods: The hematuria amylase recovery time were observed and recorded in the two groups. The contents of nutritional and biochemical indicators (total serum protein, TP; prealbumin, PA; albumin, ALB) were detected before and after nursing intervention in the two groups, and the ratios of CD4+T lymphocytes, CD4+/CD8+T lymphocytes and white blood cell counting (WBC) were monitored. Before and after nursing intervention, the levels of inflammatory factors interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were tested, and the scores of acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) and computed tomography (CT) were evaluated. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were emplyed for the evaluation of the anxiety and depression status of patients before and after nursing intervention, Short-Form 36-item Health Survey (SF-36) for the assessment of the quality of life (QOL) and the self-made (hospital) nursing satisfaction questionnaire for the determination of the nursing satisfaction of patients in the two series after nursing intervention. Results: In comparison with CG, the hospitalization time, hospitalization cost, and the hematuria amylase recovery time were statistically less in RG (P<0.05). Compared with CG, the levels of nutritional and biochemical indicators TP, AP, ALB were statistically higher in RG (P<0.05), the ratios of CD4+T lymphocytes and CD4+/CD8+T lymphocytes were statistically higher (P<0.05), and the WBC level was statistically lower after nursing intervention (P<0.05). In comparison with CG, the IL-6, TNF-α and CRP levels were statistically lower and the IL-10 level was statistically higher in RG after nursing intervention (P<0.05). RG presented statistically lower APACHE II and CT scores, evidently decreased SAS and SDS scores, and significantly higher QOL scores and nursing satisfaction than CG after nursing intervention (P<0.05). Conclusion: HQN intervention is markedly effective in the treatment of AP patients with ENS. It can statistically shorten the length of hospital stay, lower the economic pressure, and reduce the hematuria amylase recovery time and the incidence of complications. Also, it can enhance the nutritional health level and immune function of patients, reduce the inflammatory reaction, alleviate patients’ adverse emotions of anxiety and depression, and meliorate their QOL and prognosis.
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