Abstract
Population explosion in certain parts of the world, especially in the developing countries like India, has led to a continuous effort towards development. The therapeutic properties of medicinal plants are conditioned by the presence in their organs of active substances, such as alkaloids, glycosides, vitamins, tanins and coumarin compounds which physiologically affects the bodies of humans and animals or which are biologically active in relation to causative agents of various diseases. The tribal people and ethnic races throughout the world have developed their own medical practices. The root extract of Abutilon indicum (L.) (Beng-Potari) was selected for the present experimental study of antifertility activity in the male albino mice. Treatment after seven days (dosage of 1 g/kg.bw./day), the gradual decease in the seminiferous tubular area. Nuclear diameter of epithelial cells and tubular area of the epididymis, Sertoli cells and sperm populations were also decreased significantly.
Highlights
Population explosion in certain parts of the world, especially in the developing countries like India, has led to a continuous effort towards development of safer, reversible and easy to deliver modes of contraception
During the course of study some multinucleated germ cells were observed within the tubules, which seemed to be formed by the coalescence of developing spermatids or secondary spermatocytes
These testicular degenerative features indicate that the extract of Abutilon indicum (L.) may inhibit the gonadotrophin (FSH), which is essential for spermatogenesis
Summary
Population explosion in certain parts of the world, especially in the developing countries like India, has led to a continuous effort towards development of safer, reversible and easy to deliver modes of contraception. A number of articles have been published, suggesting the possibility of systemic contraceptives interfering with fertility by acting at any of the vulnerable points associated with reproduction (Henshaw, 1953). Some of these plants have been mentioned repeatedly in the literature as antifertility agents (Lans et al, 2003; Lans, 2007; Sandhya, B., Thomas, S., Isabel et al, 2006).
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