Abstract
The androgen receptor inhibitors (ARI) enzalutamide, apalutamide, and darolutamide have been recommended for the treatment of non-metastatic castration-resistant prostate cancer (nmCRPC). With the publication of the final analysis of the overall survival of the patients in the three main randomized controlled trials that evaluated these drugs, a systematic analysis of their benefits and risks is once again necessary. The aim of this study is to conduct a meta-analysis of the efficacy and safety of ARIs for the treatment of nmCRPC.
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