Abstract
Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation.See research article http://wwww.biomedcentral.com/1471-2148/12/25
Highlights
heat shock protein 90 (Hsp90) reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation
In a narrow interpretation of these data, Hsp90 is seen as a contributor to the extraordinary resistance of bio logical systems to common perturbations such as muta tion
In a new and stressful environm ent, cellular demand for Hsp90 will increase beyond its supply, mimicking the effects of artificial depletion
Summary
Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. A recent paper in BMC Evolutionary Biology by Chen and Wagner [3] describes a polymorphism in the Droso phila melanogaster Hsp90 promoter, where a trans posable element insertion halved Hsp90 expression and activity.
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