Abstract
We have demonstrated that red blood cell (RBC) membranes in membranopathies are targets for inducible Hsp70 family members. A similar phenomenon was observed in several types of hereditary haemolytic anaemias. One common feature of the inherited haemolytic anaemias is that the mutations are manifested in the form of an altered RBC membrane structure resulting in premature cell destruction. Hence, we propose that malfolded (and mutated) RBC membrane proteins are recognised by Hsp70 protein. Although the function of Hsp70 family members as a ‘quality control system’ is well known, this is the first report of their presence in human anaemias.
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