Abstract
MicroRNAs (miRNAs) are gene regulators involved in numerous diseases including cancer, heart disease, neurological disorders, vascular abnormalities and autoimmune conditions. Although hsa-mir-499 rs3746444 polymorphism was shown to contribute to the susceptibility of multiple genes to cancer, the data have yielded conflicting results. Therefore, this meta-analysis was performed to provide a comprehensive assessment of po-tential association between hsa-mir-499 rs3746444 polymorphism and cancer risk. In this meta-analysis, a total of 9 articles regarding 10 eligible case-control studies in English (including 6134 cases and 7141 controls) were analyzed. No significant association between hsa-mir-499 rs3746444 polymorphism and overall cancer risk was demonstrated. However, an increased risk was observed in the subgroup of breast cancer patients (G allele vs A allele: OR = 1.10, 95% CI = 1.00-1.20; Pheterogeneity = 0.114; I2 = 53.9%) and population-based studies (G allele vs A allele: OR = 1.12, 95% CI = 1.00-1.25; Pheterogeneity = 0.062; I2 = 64.0%). The findings suggested an association be-tween hsa-mir-499 rs3746444 polymorphism and increased risk to breast cancer.
Highlights
MicroRNAs are short non-coding single-stranded RNA molecules involved in both physiological and pathological processes, exerting their regulatory effects by suppressing translation or by inducing the cleavage of target RNA transcripts[1]
A sizeable number of studies have been performed to investigate the role of hsa-mir-499 rs3746444 polymorphism in several cancer types such as breast cancer[12,13], lung cancer[14], gallbladder cancer[15], squamous cell carcinoma of the head and neck (SCCHN)[16], prostatic cancer[17], gastric cancer[18], cervical squamous cell carcinoma (CSCC)[19] and bladder cancer[20], these existing eligible studies have yielded contradictory results, needing to be investigated further
The results showed no significant association between hsa-mir-499 rs3746444 polymorphism and cancer risk among Asians and Caucasians in all comparison models tested (Table 2)
Summary
MicroRNAs (miRNAs) are short (around 22-nt) non-coding single-stranded RNA molecules involved in both physiological and pathological processes, exerting their regulatory effects by suppressing translation or by inducing the cleavage of target RNA transcripts[1]. MiRNAs are regulators of gene expression that provide a regulation for a broad range of biological processes including cancer development, cellular. One study has demonstrated that both the α- and β-isoform of the calcineurin catalytic subunit are direct targets of miR-499, which inhibits apoptosis of cardiomyocytes through a suppression of calcineurin-mediated dephosphorylation of dynamin-related protein-1 (Drp1)[8]. Landi et al.[11] reported seven SNPs located in seven pre-miRNA hairpin regions, which include the polymorphism within hsa-mir499. We performed a meta-analysis including subgroup analysis from all eligible studies to obtain a more precise assessment of the association between hsamir-499 rs3746444 polymorphism and cancer risk
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