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Abstract
BackgroundMicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results.Methodology/Principal FindingsWe conducted a meta-analysis of 15 studies that included 9,341 cancer cases and 10,569 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR = 1.18, 95% CI = 1.03–1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR = 1.11, 95%CI = 1.01–1.23, P heterogeneity = 0.210) and lung cancer risk (OR = 1.25, 95%CI = 1.06–1.46, P heterogeneity = 0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR = 1.24, 95% CI = 1.07–1.43, P heterogeneity = 0.006).ConclusionsThese findings supported that hsa-miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of cancers.
Highlights
MicroRNAs are a class of noncoding evolutionarily conserved small RNA molecules with,22 nucleotides in length that inhibit gene expression
These findings supported that hsa-miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of cancers
15 studies that included a total of 9,341 cancer cases and 10,569 controls appeared to meet the inclusion criteria and were subjected to further examination
Summary
MicroRNAs (miRNAs) are a class of noncoding evolutionarily conserved small RNA molecules with ,22 nucleotides in length that inhibit gene expression. MiRNAs play important roles in the etiology of many human diseases through post-transcriptionally regulating the expression of approximately one third of all human genes [3]. MiRNAs have been involved in the etiology, progression and prognosis of cancer [4]. Pineau et al found that the expression levels of some miRNAs change gradually during the progression of liver disease and miR-221 is capable of stimulating tumor growth possibility [6]. MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results
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