Hürthle cell carcinoma. Cooperative analysis of 2 oncologic hospitals of Buenos Aires city

Abstract

Background: in view of its low incidence, cytological difference with follicular cells carcinoma (FCC), higher lymphatic spread, little 131I avidity and less specific survival than FCC, Hurthle Cells Carcinoma (HCC) is a polemic and controversial issue. Objective: to report experience of two oncologic Hospitals in the management of patients with his- tologic diagnosis of CCH.Material and methods: treatment of choice was total thyroidectomy in 89.4%. In 42% lateral neck dis- section was done, II-IV in 6 patients and II-V in 2 patients with resection esternocleidomatoid muscle, internal yugular vein and recurrent nerve. In 1 of these, resection of tracheal wall and tracheostomy was done. Intraoperative frozen sections confirmed diagnosis in 23%. 31.5% did not received therapeutic ablative dosis of I 131.Results: 3 patients were surgically treated for local regional disease. 2 of them developed distant metastases. 3 received radiotherapy and 1 tirosin kinase inhibitors.Conclusions: given its low incidence and absence of high quality evidence, management of HCC is controversial. Other multicentric trials with more patients and follow up are required for evaluation of different therapies, as well as better study about molecular biology of this pathology