Abstract
HRT and the efficacy of mammographic screening for breast cancer
Highlights
Existing evidence suggests that use of hormone replacement therapy (HRT) detrimentally affects the accuracy of mammographic screening for breast cancer
The relationship between current HRT use versus non-use and screening accuracy was assessed according to the risk of interval versus screen-detected cancer, the risk of being referred for assessment following screening with no subsequent diagnosis of breast cancer and the proportion of women diagnosed with screen-detected cancers measuring 10 mm or less
Based on a two year screening interval, the crude sensitivity of mammographic screening was 64.8% in current HRT users and 77.3% in non-users
Summary
Specificity and small invasive breast cancer detection rate according to HRT use in a population-based study of women aged 40 and over. This study adds to the increasing body of evidence demonstrating a decrease in the sensitivity and specificity of mammographic breast cancer screening in current hormone replacement therapy (HRT) users, compared to non-users. Since HRT use is common in women attending breast cancer screening and has been shown to increase the risk of breast cancer itself, this has important implications for screening programmes and for women attending them. The broad finding of an increased risk of interval cancer and 'false positive' screens in women currently using HRT is likely to be real
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