HRRD: a manually-curated database about the regulatory relationship between HPV and host RNA

Bingqing Yan,Bozhi Wang,Fen Ma,Tianyang Liu,Xiaoyu Dong,Siyang Yu,Sajjad Hussain,Lanlan Wei,Siwei Zhang

doi:10.1038/s41598-020-76719-6

Abstract

HPV (Human papilloma virus) is a kind of small double-stranded DNA viruses which is extremely associated with different cancers. The roles HPV plays in the host were gradually identified through the interaction between it (including its early genes) and host RNA. In recent years, increasing numbers of studies in HPV-related cancers have been published showing the relationship between HPV and host RNA. Here, we present a database named HRRD, which contains the regulatory relationship between HPV and RNA (mRNA, miRNA and lncRNA). The information was extracted from 10,761 papers in PubMed (up to December 1st, 2019). In addition, the sequence map of HPV (198 genotypes) is also contained. HRRD was designed as a user-friendly web-based interface for data retrieval. It integrated the information of interaction between HPV and RNA, which reflects the relationship between HPV and host. We hope HRRD will further provide a comprehensive understanding of HPV in carcinogenesis and prognosis. HRRD is freely accessible at www.hmuhrrd.com/HRRD.

Highlights

Human papilloma viruses (HPVs) are a group of double-stranded circular DNA viruses with about 8000 nucleotides in size
Host RNA can be divided into coding RNA and non-coding RNA. mRNA is the main type of coding RNA, while miRNA and lncRNA are two kinds of non-coding RNA which are popular in the field of research
HPV participates in cancer metastasis, prognosis, immune response and so on

Summary

Introduction

Human papilloma viruses (HPVs) are a group of double-stranded circular DNA viruses with about 8000 nucleotides in size. HPV plays an important role in carcinogenesis, and participate in host tumor immunity, prognosis, drug resistance and so on. All these functions are achieved through the interaction between HPV and host RNA. HPVs influence host cells (normal/cancer cells) by regulating the expression of these RNAs (Fig. 1). By affecting the expression of host RNA, HPV can lead to the occurrence and development of cancers, and has a huge impact on the treatment, immunity and prognosis of cancers. It has been reported recently that host RNA can affect the expression of HPV in converse. It will contribute to providing a comprehensive web-based resource for HPV and host, and data support for HPV-related research

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