Abstract
The development of effective prophylactic vaccines against an infectious agent (human papillomavirus, HPV) that causes cervical cancer is a major milestone in preventive medicine. In this article, Schwarz and co-workers demonstrated persistence for 6 years following immunisation with the Cervarix™ vaccine of high-titer antibodies to HPV–16/18 in the circulation and in cervicovaginal fluid in women aged 15–55 years. Using statistical modelling it was also determined that antibody levels would persist for at least 20 years. An exception was the possible loss of persistent immunity for women aged 46–55 years. Several questions remain unanswered in relation to the HPV vaccine. Continued analysis of the efficacy and consequences of HPV vaccination, especially in resource-poor areas, remains a priority. None.
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