Abstract
A randomized, controlled trial has shown human papillomavirus (HPV) DNA testing with and without liquid-based cytology to be more sensitive but less specific than conventional Papanicolaou smears for detection of precancerous lesions of the cervix. The lead-time advantage of early detection of precancerous lesions by HPV DNA testing resulted in cervical cancer reduction; however, an increased detection of possibly regressive precancerous lesions could result in unnecessary treatment, especially in women aged 25–34 years.
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