Abstract
<i>Background</i>: Moisture content varies in capsules made from different materials. Gelatin capsules contain 13-16% moisture. HPMC (Hydroxypropyl methyl cellulose or Hypromellose) capsules may contain moisture 2- 8%. Usual HPMC capsules have inherently low moisture content which allows for the encapsulation of ingredients that are sensitive to moisture and are hygroscopic in nature. This has greatly broadened the scope of capsules in drug delivery. Moisture content of HPMC capsules can be reduced as low as 2%. HPMC capsules lower moisture content is better for moisture sensitive and hygroscopic products. <i>Objective</i>: Low moisture content of HPMC capsules help to improve stability of moisture sensitive active pharmaceutical and active nutraceutical active ingredients. This is illustrated with examples. Different properties of HPMC capsules helps targeted delivery. It offers some special advantages for nutraceutical products. It also helps to improve physical stability of capsules. Liquid filled hard capsules provide many options and are commonly used for nutraceutical products.
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